2024-03-29T05:28:25Zhttp://digital.csic.es/dspace-oai/requestoai:digital.csic.es:10261/1212602016-02-18T03:40:02Zcom_10261_31com_10261_3col_10261_284
2015-08-20T10:02:42Z
urn:hdl:10261/121260
Nano-objects for addressing the control of nanoparticle arrangement and performance in magnetic hyperthermia
Andreu, Irene
Natividad, Eva
Solozábal, Laura
Roubeau, Olivier
Ministerio de Economía y Competitividad (España)
European Commission
Universidad de Zaragoza
Banco Santander
Consejo Superior de Investigaciones Científicas (España)
Iron oxide magnetic nanoparticles
PLGA
Silica
Nano-object
Magnetic interactions
Specific absorption rate
One current challenge of magnetic hyperthermia is achieving therapeutic effects with a minimal amount of nanoparticles, for which improved heating abilities are continuously pursued. However, it is demonstrated here that the performance of magnetite nanocubes in a colloidal solution is reduced by 84% when they are densely packed in three-dimensional arrangements similar to those found in cell vesicles after nanoparticle internalization. This result highlights the essential role played by the nanoparticle arrangement in heating performance, uncontrolled in applications. A strategy based on the elaboration of nano-objects able to confine nanocubes in a fixed arrangement is thus considered here to improve the level of control. The obtained specific absorption rate results show that nanoworms and nanospheres with fixed one- and two-dimensional nanocube arrangements, respectively, succeed in reducing the loss of heating power upon agglomeration, suggesting a change in the kind of nano-object to be used in magnetic hyperthermia.
2015-08-20T10:02:42Z
2015-08-20T10:02:42Z
2015-02
artículo
ACS Nano 9(2): 1408-1419 (2015)
1936-0851
http://hdl.handle.net/10261/121260
10.1021/nn505781f
1936-086X
http://dx.doi.org/10.13039/501100003329
http://dx.doi.org/10.13039/501100000780
http://dx.doi.org/10.13039/501100007041
http://dx.doi.org/10.13039/501100003339
http://dx.doi.org/10.13039/100010784
eng
http://dx.doi.org/10.1021/nn505781f
Sí
closedAccess
American Chemical Society