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openAccess2009_Torreira et al_PNAS.pdf.jpg9-Jan-20093D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertaseTorreira, Eva ; Tortajada, Agustín ; Montes, Tamara ; Rodríguez de Córdoba, Santiago ; Llorca, Óscar artículo
openAccessTesis_Tortajada_Alonso_Agustin_2012.pdf.jpg2012Análisis estructural y funcional de proteínas del complemento asociadas con patología.Tortajada, Agustín tesis doctoral
openAccess15-Aug-2012Atypical Hemolytic Uremic Syndrome-Associated variants and autoantibodies impair binding of factor H and factor H-Related protein 1 to Pentraxin 3Kopp, Anne; Strobel, Stefanie; Tortajada, Agustín ; Rodríguez de Córdoba, Santiago ; Sánchez-Corral, Pilar ; Prohászka, Zoltán; López-Trascasa, Margarita; Józsi, Mihályartículo
openAccessJCI 123 (6) 2013-Óscar Llorca.pdf.jpgJun-2013C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulationTortajada, Agustín ; Yébenes, Hugo; Anter, Jauoad; García-Fernández, Jesús; Martínez-Barricarte, Rubén ; Llorca, Óscar ; Rodríguez de Córdoba, Santiago artículo
closedAccessrestringido.pdf.jpg1-Dec-2009Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertaseTorreira, Eva ; Tortajada, Agustín ; Montes, Tamara ; Rodríguez de Córdoba, Santiago ; Llorca, Óscar artículo
openAccess2012_Rodriguez de Cordoba et al_Immunobiology.pdf.jpgNov-2012Complement dysregulation and disease: from genes and proteins to diagnostics and drugsRodríguez de Córdoba, Santiago ; Tortajada, Agustín ; Harris, Claire L.; Morgan, B. Paulartículo
openAccess2012_Tortajada et al_Kidney Int.pdf.jpgJan-2012Complement factor H variants I890 and L1007 while commonly associated with atypical haemolytic uremic syndrome are polymorphisms with no functional significanceTortajada, Agustín ; Pinto, Sheila ; Martínez-Ara, Jorge; López-Trascasa, Margarita; Sánchez-Corral, Pilar ; Rodríguez de Córdoba, Santiago artículo
openAccessMartin Merinero et al_KI_final_2018.pdf.jpgFeb-2018Complete functional characterization of disease-associated genetic variants in the complement factor H geneMartín Merinero, Héctor; Pinto, Sheila ; García-Fernández, Jesús; Arjona, Emilia; Tortajada, Agustín ; Rodríguez de Córdoba, Santiago artículo
closedAccessrestringido.pdf.jpgJan-2018Factor H competitor generated by gene conversion events associates with atypical hemolytic uremic syndromeGoicoechea de Jorge, Elena ; Tortajada, Agustín ; Pinto, Sheila ; Gastoldi, Sara; Merinero, Hector; García-Fernández, Jesús; Arjona, Emilia; Cao, Mercedes; Remuzzi, Giuseppe; Noris, Marina; Rodríguez de Córdoba, Santiago artículo
openAccessOct-2016Factor H-related protein 3 (FHR-3) inhibits factor H binding to pentraxins and malondialdehyde epitopes, and activates the alternative pathway via C3b bindingCsincsi, Ádám I.; Pouw, Richard B.; Tortajada, Agustín ; Rodríguez de Córdoba, Santiago ; Wouters, Diana; Józsi, Mihálycomunicación de congreso
openAccess2017-European Journal of Immunology-postprint.compressed.pdf.jpgMar-2017Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applicationsSubías, Marta; Yébenes, Hugo; Rodríguez-Gallego, César; Martín-Ambrosio, Adrián; Domínguez, Mercedes; Tortajada, Agustín ; Rodríguez de Córdoba, Santiago ; Llorca, Óscar artículo
openAccess2009_Montes et al_PNAS.pdf.jpg2-Mar-2009Functional basis of protection against age-related macular degeneration conferred by a common polymorphism in complement factor BMontes, Tamara ; Tortajada, Agustín ; Morgan, B. Paul; Rodríguez de Córdoba, Santiago ; Harris, Claire L.artículo
openAccessRodriguez de Cordoba et al_2014_Sem Thromb Hem.pdf.jpgApr-2014Genetics of atypical hemolytic uremic syndrome (aHUS)Rodríguez de Córdoba, Santiago ; Subías, Marta; Pinto, Sheila ; Tortajada, Agustín artículo
openAccessHow novel structures inform understanding 2017.pdf.jpgJan-2018How novel structures inform understanding of complement functionGoicoechea de Jorge, Elena ; Yébenes, Hugo; Serna, Marina; Tortajada, Agustín ; Llorca, Óscar ; Rodríguez de Córdoba, Santiago artículo
openAccessJCI43343 v1.pdf.jpg13-Sep-2010Human C3 mutation reveals a mechanism of dense deposit disease pathogenesis and provides insights into complement activation and regulationMartínez-Barricarte, Rubén ; Heurich, Meike; Valdés-Cañedo, Francisco; Vázquez-Martul, Eduardo; Torreira, Eva ; Montes, Tamara ; Tortajada, Agustín ; Pinto, Sheila ; López-Trascasa, Margarita; Morgan, B. Paul; Llorca, Óscar ; Harris, Claire L.; Rodríguez de Córdoba, Santiago artículo
closedAccessrestringido.pdf.jpgMay-2008Measurement of factor H variants in plasma using variant-specific monoclonal antibodies: application to assessing risk of age-related macular degenerationHakobyan, Svetlana; Harris, Claire L.; Tortajada, Agustín ; Goicoechea de Jorge, Elena ; García-Layana, Alfredo; Fernández-Robredo, Patricia; Rodríguez de Córdoba, Santiago ; Morgan, B. Paulartículo
openAccess2015_Recalde et al_JASN.pdf.jpg16-Sep-2015Molecular basis of factor H R1210C association with ocular and renal diseasesRecalde, Sergio; Tortajada, Agustín ; Subías, Marta; Anter, Jauoad; Pinto, Sheila ; Rodríguez de Córdoba, Santiago artículo
openAccessOct-2016Prevalent FHR-1 mutant protein generated by gene conversion reveals crucial role of factor H polymorphisms in atypical Hemolytic Uremic Syndrome (aHUS)Tortajada, Agustín ; Pinto, Sheila ; Gastoldi, Sara; García-Fernández, Jesús; Merinero, Hector; Arjona, Emilia; Noris, Marina; Rodríguez de Córdoba, Santiago comunicación de congreso
openAccessserum_properdin_Corvillo.pdf.jpgApr-2016Serum properdin consumption as a biomarker of C5 convertase dysregulation in C3 glomerulopathyCorvillo, Fernando; María Bravo García-Morato; Nozal, Pilar; Garrido, Sofía; Tortajada, Agustín ; Rodríguez de Córdoba, Santiago ; López-Trascasa, Margaritaartículo
openAccessJul-2013Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdinAlcorlo, Martín ; Tortajada, Agustín ; Rodríguez de Córdoba, Santiago ; Llorca, Óscar artículo