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Browsing by Author Barasoain, Isabel

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closedAccess12-Apr-2001Centrosome and spindle pole microtubules are main targets of a fluorescent taxoid inducing cell deathAbal, Miguel; Souto, André A.; Amat-Guerri, Francisco ; Acuña, A. Ulises ; Andreu, José Manuel ; Barasoain, Isabel artículo
openAccesscyclostreptin_Buey.pdf.jpgJan-2007Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sitesBuey, Ruben M.; Calvo, Enrique; Barasoain, Isabel ; Pineda, Oriol; Edler, Michael C.; Matesanz, Ruth ; Cerezo, Gemma; Vanderwal, Christopher D.; Day, Billy W.; Sorensen, Erik J.; López, Juan Antonio; Andreu, José Manuel ; Hamel, Ernest; Díaz, José Fernando artículo
closedAccessrestringido.pdf.jpgJan-2012Cyclostreptin Derivatives Specifically Target Cellular Tubulin and Further Map the Paclitaxel SiteCalvo, Enrique; Barasoain, Isabel ; Matesanz, Ruth ; Pera, Benet ; Camafeita, Emilio; Pineda, Oriol; Hamel, Ernest; Vanderwal, Christopher D.; Andreu, José Manuel ; López, Juan Antonio; Díaz, José Fernando artículo
closedAccessMay-2011Design and Synthesis of Pironetin Analogues with Simplified Structure and Study of Their Interactions with MicrotubulesMarco, J. Alberto; García-Plab, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara ; Notararigo, Sara ; Díaz, José Fernando ; Barasoain, Isabel artículo
closedAccessOct-1998Effect of 2′-OH acetylation on the bioactivity and conformation of 7-O-[N-(4′-fluoresceincarbonyl)-l-alanyl]taxol. A NMR-fluorescence microscopy studyBarbero, José Luis ; Souto, André A.; Abal, Miguel; Barasoain, Isabel ; Evangelio, Juan A. artículo
closedAccessaccesoRestringido.pdf.jpg2015Effective GTP-replacing FtsZ inhibitors and antibacterial mechanism of actionArtola, M.; Ruiz-Avila, Laura B.; Vergonos, A.; Huecas, Sonia ; Araújo-Bazán, Lidia ; Martin-Fontecha, M.; Vázquez-Villa, H.; Turrado, C.; Ramirez-Aportela, E.; Hoegl, A.; Nodwell, M.; Barasoain, Isabel ; Chacón, Pablo ; Sieber, S.A.; Andreu, José Manuel ; Lopez-Rodriguez, M.L.artículo
closedAccess15-Aug-2011Effects of C7 Substitutions in a High Affinity Microtubule-Binding Taxane on Antitumor Activity and Drug TransportXiao, Xi; Wu, Ju; Trigili, Chiara ; Chen, Hui; Chu, Joseph W.K.; Zhao, Ying; Lu, Peihua; Sheng, Li; Li, Yan; Sharom, Frances J.; Barasoain, Isabel ; Díaz, José Fernando ; Fang, Wei-shuo S.artículo
openAccessJ. Biol. Chem.-2003-D__az-8407-19.pdf.jpg7-Mar-2003Fast kinetics of Taxol binding to microtubules:effects of solution variables and microtubule-associated proteinsDíaz, José Fernando ; Barasoain, Isabel ; Andreu, José Manuel artículo
closedAccess1998Fluorescent taxoids as probes of the microtubule cytoskeletonEvangelio, Juan A. ; Abal, Miguel; Barasoain, Isabel ; Souto, André A.; Lillo, M. Pilar ; Acuña, A. Ulises ; Amat-Guerri, Francisco ; Andreu, José Manuel artículo
openAccessOncology Reports.2018_Sánchez-Carranza.pdf.jpg18-Apr-2018Gallic acid sensitizes paclitaxel-resistant human ovarian carcinoma cells through an increase in reactive oxygen species and subsequent downregulation of ERK activationSánchez-Carranza, Jessica Nayelli; Díaz, José Fernando ; Redondo-Horcajo, Mariano ; Barasoain, Isabel ; Álvarez, Laura ; Lastres, Pedro ; Romero, Antonio ; Aller, Patricio ; González-Maya, Leticiaartículo
openAccessScientific reports(2018)4242.pdf.jpg2018High-affinity ligands of the colchicine domain in tubulin based on a structure-guided designBueno, Oskía; Estévez Gallego, J.; Martins, S.; Prota, Andrea E.; Gago, Federico ; Gómez-SanJuan, Asier; Camarasa Rius, María José ; Barasoain, Isabel ; Steinmetz, Michel O.; Díaz, Fernando J.; Peréz-Pérez, María-Jesús ; Liekens, Sandra; Priego, Eva María artículo
closedAccessrestringido.pdf.jpgMay-2011Highly Stereoselective Total Synthesis of (+)-9-epi-Dictyostatin and (–)-12,13-bis-epi-Dictyostatin Eur. JZanato, Chiara; Pignataro, Luca; Ambrosi, Andrea; Hao, Zhongyan; Trigili, Chiara ; Díaz, José Fernando ; Barasoain, Isabel ; Gennari, Cesareartículo
closedAccessaccesoRestringido.pdf.jpg2000Induction of apoptosis in leukemic cells by the reversible microtubule-disrupting agent 2-methoxy-5-(2', 3', 4'-trimethoxyphenyl)-2, 4, 6- cycloheptatrien-1-one: Protection by bcl-2 and bcl-x (L) and cell cycle arrestGajate, Consuelo; Barasoain, Isabel ; Andreu, José Manuel ; Mollinedo, Faustino artículo
openAccessPNAS_.Unterhauser_2019.pdf.jpg26-Feb-2019Klebsiella oxytoca enterotoxins tilimycin and tilivalline have distinct host DNA-damaging and microtubulestabilizing activitiesUnterhauser, Katrin; Poltl, Lisa; Schneditz, Georg; Kienesberger, Sabine; Glabonjat, Ronald A.; Kitsera, Maksym; Pletz, Jakob; Josa-Prado, Fernando; Dornisch, Elisabeth; Lembacher-Fadum, Christian; Roier, Sandro; Gorkiewicz, Gregor; Lucena, Daniel; Barasoain, Isabel ; Kroutil, Wolfgang; Wiedner, Marc; Loizou, Joanna I.; Breinbauer, Rolf; Díaz, José Fernando ; Schild, Stefan; Hog̈enauer, Christoph; Zechner, Ellen L.artículo
openAccessJ. Biol. Chem.-2005-Díaz-3928-37.pdf.jpg2005Macromolecular accessibility of fluorescent taxoids bound at a paclitaxel binding site in the microtubule surfaceDíaz, José Fernando ; Barasoain, Isabel ; Souto, André A.; Amat-Guerri, Francisco ; Andreu, José Manuel artículo
closedAccess2-May-2011Mechanism of Action of Cytotoxic Macrolides Amphidinolide X and J.Trigili, Chiara ; Pera, Benet ; Barbazanges, Marion; Cossy, Janine; Meyer, Christophe; Pineda, Oriol; Rodríguez-Escrich, Carles; Urpí, Félix; Vilarrasa, Jaume; Díaz, José Fernando ; Barasoain, Isabel artículo
openAccess2287280_T3.pdf.jpg16-Dec-2007Método de detección y evaluación de compuestos miméticos de paclitaxelAndreu, José Manuel ; Díaz, José Fernando ; Barasoain, Isabel patente
closedAccessaccesoRestringido.pdf.jpg2005Microtubule interactions with chemically diverse stabilizing agents: Thermodynamics of binding to the paclitaxel site predicts cytotoxicityMartínez Buey, Rubén ; Barasoain, Isabel ; Jackson, Evelyn; Meyer, Arndt; Giannakakou, Paraskevi; Paterson, Ian; Mooberry, Susan; Andreu, José Manuel ; Díaz, José Fernando artículo
openAccess2017 Tang et al.pdf.jpg3-Jun-2017Modification of C-seco taxoids through ring tethering and substituent replacement leading to effective agents against tumor drug resistance mediated by βIII-Tubulin and P-glycoprotein (P-gp) overexpressions.Tang, Yong; Rodríguez-Salarichs, Javier; Estévez Gallego, J.; Balaguer, Francisco de Asís; Redondo-Horcajo, Mariano ; Lucena-Agell, Daniel; Barasoain, Isabel ; Díaz, José Fernando ; Fang, Wei-shuo S.artículo
closedAccess16-Aug-2010Molecular recognition of peloruside A by microtubules. The C24 primary alcohol is essential for biological activity.Pera, Benet ; Razzak, Mina; Trigili, Chiara ; Pineda, Oriol; Canales, Ángeles ; Martínez Buey, Rubén ; Jiménez-Barbero, Jesús ; Northcote, Peter; Paterson, Ian; Barasoain, Isabel ; Díaz, José Fernando artículo