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openAccessEstablishment of a screening platform based on human coronavirus.pdf.jpg21-abr-2023Establishment of a screening platform based on human coronavirus OC43 for the identification of microbial natural products with antiviral activityMartínez-Arribas, Blanca; Annang, Frederick; Díaz-González, Rosario; Pérez-Moreno, Guiomar; Martín, Jesús; Mackenzie, Thomas; Castillo, Francisco; Reyes, Fernando; Genilloud, Olga; Ruiz-Pérez, Luis Miguel; Vicente, Francisca; Ramos, María C.; González-Pacanowska, Dolorespreprint
openAccessKlug-2019-Evaluation-of-a-class-of-isatinoids.pdf.jpg8-feb-2019Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agentsKlug, Dana M.; Díaz-González, Rosario; Pérez-Moreno, Guiomar; Ceballos-Pérez, Gloria; García-Hernández, Raquel CSIC ORCID; Gómez-Pérez, Veronica; Ruiz-Pérez, Luis Miguel; Rojas-Barros, Domingo I.; Gamarro, Francisco; González-Pacanowska, Dolores; Martínez-Martínez, María S.; Manzano, Pilar; Ferrins, Lori; Caffrey, Conor R.; Navarro, M.; Pollastri, M.P.artículo
openAccessExposure_pntd.PDF.jpg6-mar-2015Exposure of Trypanosoma brucei to an N-acetylglucosamine-Binding Lectin Induces VSG Switching and Glycosylation Defects Resulting in Reduced InfectivityCastillo Acosta, Víctor M.; Ruiz-Pérez, Luis Miguel; Van Damme, Els J. M.; Balzarini, Jan; González-Pacanowska, Doloresartículo
openAccess8-nov-2020Hit-to lead and target identification studies within a novel class of anti-trypanosomal agentsFerrins, L; Díaz González, R.; Ceballos-Pérez, G.; Saura, A.; Pérez-Moreno, Guiomar; García-Hernández, Raquel CSIC ORCID; Bosch-Navarrete, Cristina; Gamarro, Francisco; Ruiz-Pérez, Luis Miguel; González-Pacanowska, Dolores; Navarro, M.; Pollastri, M.actas de congreso
openAccess8-mar-2020Hit-to-lead and target identification studies within a novel class of antitrypanosomal agentsFerrins, L; Díaz-González, Rosario; Ceballos-Pérez, Gloria; Saura, A.; Pérez-Moreno, Guiomar; García-Hernández, Raquel CSIC ORCID; Boch-Navarrete, C; Gamarro, Francisco; Ruiz-Pérez, Luis Miguel; González-Pacanowska, Dolores; Navarro, M.; Pollastri, M.actas de congreso
openAccessCastillo-Acosta et al., 2009.pdf.jpg1-abr-2009Identification of a residue critical for the excision of 3′-blocking ends in apurinic/apyrimidinic endonucleases of the Xth familyCastillo-Acosta, Victor M.; Ruiz-Pérez, Luis Miguel; Yang, Wei; González-Pacanowska, Dolores; Vidal, Antonio E. CSIC ORCID artículo
openAccess8-mar-2020Identification of SAMHD1 orthologues in Trypanosoma brucei reveals novel features of pyrimidine dNTP homeostasisYagüe Capilla, M; Castillo-Acosta, Victor M.; Valente, M; Boch-Navarrete, C; Ruiz-Pérez, Luis Miguel; González-Pacanowska, Doloresactas de congreso
closedAccessaccesoRestringido.pdf.jpg1-dic-2012Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma bruceiCastillo-Acosta, Víctor M.; Aguilar-Pereyra, Fernando; Bart, Jean-Mathieu; Navarro, Miguel; Ruiz-Pérez, Luis Miguel; Vidal, Antonio E. CSIC ORCID ; González-Pacanowska, Doloresartículo
openAccessVidal et al., 2022.pdf.jpg18-abr-2022Inosine triphosphate pyrophosphatase from Trypanosoma brucei cleanses cytosolic pools from deaminated nucleotidesVidal, Antonio E. CSIC ORCID ; Yagüe-Capilla, Miriam; Martínez-Arribas, Blanca; García-Caballero, Daniel; Ruiz-Pérez, Luis Miguel; González-Pacanowska, Doloresartículo
openAccessInsights_2017.pdf.jpg17-ago-2017Insights into the role of endonuclease V in RNA metabolism in Trypanosoma bruceiGarcía-Caballero, Daniel; Pérez-Moreno, Guiomar; Estévez, Antonio M. CSIC ORCID; Ruiz-Pérez, Luis Miguel; Vidal, Antonio E. CSIC ORCID ; González-Pacanowska, Doloresartículo
closedAccessaccesoRestringido.pdf.jpg2018MDN-0185, an Antiplasmodial Polycyclic Xanthone Isolated from Micromonospora sp. CA-256353Annang, Frederick; Pérez-Victoria, Ignacio; Pérez-Moreno, Guiomar; Domingo, Elizabeth; González, Ignacio; Tormo, José Rubén; Martín, Jesús; Ruiz-Pérez, Luis Miguel; Genilloud, Olga; González-Pacanowska, Dolores; Vicente, Francisca; Reyes, Fernandoartículo
openAccessGigante_full_article.pdf.jpg2014Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylaseGigante, Alba CSIC ORCID; Priego, Eva María CSIC ORCID; Sánchez-Carrasco, Paula; Ruiz-Pérez, Luis Miguel; Vande Voorde, Johan; Camarasa Rius, María José CSIC ORCID; Balzarini, Jan; González-Pacanowska, Dolores; Peréz-Pérez, María-Jesús CSIC ORCID artículo
openAccessWO2015051422_A1.pdf.jpg16-abr-2015New pradimicin derivatives for the treatment of diseases caused by kinetoplastidsBalzarini, Jan; González-Pacanowska, Dolores; Ruiz-Pérez, Luis Miguel; Castillo Acosta, Víctor M.; Agarashi, Yasuhirosolicitud de patente
closedAccessaccesoRestringido.pdf.jpg15-ago-2017Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma bruceiPham, ThanhTruc; Walden, Madeline; Butler, Christopher; Díaz-González, Rosario; Pérez-Moreno, Guiomar; Ceballos-Pérez, Gloria; Gómez-Pérez, Veronica; García-Hernández, Raquel CSIC ORCID; Zecca, Henry; Krakoff, Emma; Kopec, Brian; Ichire, Ogar; Mackenzie, Caden; Pitot, Marika; Ruiz-Pérez, Luis Miguel; Gamarro, Francisco; González-Pacanowska, Dolores; Navarro, M.; Dounay, Amy B.artículo
openAccess8-abr-2018Novel nucleotidases involved in Trypanosoma brucei pyrimidine homeostasisYagüe-Capilla, M; Castillo-Acosta, Victor M.; Valente, M; Bosch-Navarrete, Cristina; Ruiz-Pérez, Luis Miguel; González-Pacanowska, Doloresactas de congreso
openAccess2020Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African TrypanosomiasisTear, WF; Bag S; Díaz-González, Rosario; Ceballos-Pérez, G.; Rojas-Barros, Domingo I.; Cordon-Obras, Carlos; Pérez-Moreno, Guiomar; García-Hernández, Raquel CSIC ORCID; Martinez-Martinez, MS; Ruiz-Pérez, Luis Miguel; Gamarro, Francisco; González- Pacanowska, D.; Caffrey, CR; Ferrins, L; Manzano, Pilar; Navarro, M.; Pollastri, M.P.artículo
closedAccessaccesoRestringido.pdf.jpg18-ago-2020Strasseriolides A−D, A Family of Antiplasmodial Macrolides Isolated from the Fungus Strasseria geniculata CF-247251Annang, Frederick; Pérez-Moreno, Guiomar; González-Menendez, Víctor; Lacret, Rodney; Pérez-Victoria, Ignacio; Martín, Jesús; Cantizani, Juan; Pedro, Nuria de; Choquesillo-Lazarte, Duane CSIC ORCID; Ruiz-Pérez, Luis Miguel; González-Pacanowska, Dolores; Genilloud, Olga; Vicente, Francisca; Reyes, Fernandoartículo
closedAccessaccesoRestringido.pdf.jpg2020Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activityKlug, Dana M.; Díaz-González, Rosario; DeLano, Travis J.; Mavrogiannaki, Eftychia M.; Buske, Melissa J.; Dalton, Raeann M.; Fisher, John K.; Schneider, Katherine M.; Hilborne, Vivian; Fritsche, Melanie G.; Simpson, Quillon J.; Tear, Westley F.; Devine, William G.; Pérez-Moreno, Guiomar; Ceballos-Pérez, Gloria; García-Hernández, Raquel CSIC ORCID; Bosch-Navarrete, Cristina; Ruiz-Pérez, Luis Miguel; Gamarro, Francisco; González-Pacanowska, Dolores; Martínez-Martínez, María S.; Manzano-Chinchón, Pilar; Navarro, M.; Pollastri, M.P.; Ferrins, Lartículo
closedAccessaccesoRestringido.pdf.jpgabr-2014The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cellsRequena, Cristina E.; Pérez-Moreno, Guiomar; Ruiz-Pérez, Luis Miguel; Vidal, Antonio E. CSIC ORCID ; González-Pacanowska, Doloresartículo
closedAccessaccesoRestringido.pdf.jpgsep-2016The nucleotidohydrolases DCTPP1 and dUTPase are involved in the cellular response to decitabineRequena, Cristina E.; Pérez-Moreno, Guiomar; Horváth, András; Vértessy, Beáta G.; Ruiz-Pérez, Luis Miguel; González-Pacanowska, Dolores; Vidal, Antonio E. CSIC ORCID artículo