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openAccessMedicinal Research Reviews - 2022 - Crisman - KEAP1‐NRF2 protein protein interaction inhibitors  Design  pharmacological.pdf.jpg2023KEAP1-NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potentialCrisman, Enrique CSIC; Duarte, Pablo; Dauden, Esteban; Cuadrado, Antonio CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID ; López, Manuela G.; León, Rafael CSIC ORCID artículo de revisión
closedAccessaccesoRestringido.pdf.jpg2020Melatonin-sulforaphane hybrid ITH12674 attenuates glial response in vivo by blocking LPS binding to MD2 and receptor oligomerizationMichalska, Patrycja; Buendía Abaitua, Izaskun; Duarte, Pablo; Fernández-Mendívil, Cristina; Negredo, Pilar; Cuadrado, Antonio CSIC ORCID; López, Manuela G.; León, Rafael CSIC ORCID artículo
openAccessMarinaA_MitochondrialComplexI.pdf.jpg21-abr-2017Mitochondrial complex I deactivation is related to superoxide production in acute hypoxiaHernansanz-Agustín, Pablo; Ramos, Elena; Navarro, Elisa; Parada, Esther; Sánchez-López, Nuria; Peláez-Aguado, Laura; Cabrera-García, Daniel J.; Tello, Daniel; Buendía Abaitua, Izaskun; Marina, Anabel CSIC; Egea Maiquez, Javier; López, Manuela G.; Bogdanova, Anna; Martínez-Ruiz, Antonio CSIC ORCIDartículo
closedAccess2011N-Acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer’s diseaseGonzález Muñoz, Gema C.; Arce, Mariana P. CSIC; López, Beatriz; López, Beatriz; Romero Jódar, Alejandro CSIC ORCID; del Barrio, Laura; Martín de Saavedra, María Dolores; Egea, Javier; León, Rafael CSIC ORCID ; Villarroya, Mercedes; López, Manuela G.; García, Antonio G.; Conde, Santiago CSIC; Rodríguez-Franco, María Isabel CSIC ORCID artículo
openAccessnachain.pdf.jpg2020Na+ controls hypoxic signalling by the mitochondrial respiratory chainHernansanz-Agustín, Pablo; Choya-Foces, Carmen; Carregal-Romero, Susana; Ramos, Elena; Oliva, Tamara; Villa-Piña, Tamara; Moreno Capellán, Laura CSIC; Izquierdo-Álvarez, Alicia; Cabrera-García, J. Daniel; Cortés, Ana; Lechuga-Vieco, Ana V.; Jadiya, Pooja; Navarro, Elena; Parada, Esther; Palomino-Antolín, Alejandra; Tello, Daniel; Acín-Pérez, Rebeca; Rodríguez-Aguilera, Juan Carlos CSIC ORCID; Navas, Plácido CSIC ORCID; Cogolludo, Angel; López-Montero, Iván; Martínez-del-Pozo, Álvaro; Egea, Javier; López, Manuela G.; Elrod, John W.; Ruiz-Cabello, Jesús; Bogdanova, Anna; Enríquez, José Antonio; Martínez-Ruiz, Antonio CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2007Neuroprotection afforded by nicotine against oxygen and glucose deprivation in hippocampal slices is lost in α7 nicotinic receptor knockout miceSobrado, Mónica CSIC; López, Manuela G.; García, A. G.artículo
closedAccess2009Neuroprotective and Cholinergic Properties of Multifunctional Glutamic Acid Derivatives for the Treatment of Alzheimer’s DiseaseArce, Mariana P. CSIC; Rodríguez-Franco, María Isabel CSIC ORCID ; González Muñoz, Gema Cristina; Pérez, Concepción CSIC ORCID; López, Beatriz; Villarroya, Mercedes; López, Manuela G.; García, Antonio G.; Conde, Santiago CSICartículo
closedAccessaccesoRestringido.pdf.jpg2014Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpressionCuadrado, Antonio CSIC ORCID; López, Manuela G.; Egea Maiquez, Javierartículo
closedAccessaccesoRestringido.pdf.jpg2011Neurotoxicity Induced by Okadaic Acid in the Human Neuroblastoma SH-SY5Y Line Can Be Differentially Prevented by α7 and β2* Nicotinic StimulationBarrio, Laura del; Martín-de-Saavedra, María Dolores; Romero Jódar, Alejandro CSIC ORCID; Parada, Esther; Egea, Javier; Ávila, Jesús CSIC ORCID ; McIntosh, John Michael; Wonnacott, Susan; López, Manuela G.artículo
openAccessÁvilaJ_NeurotoxicityInducedbyOkadaic.pdf.jpg14-jun-2011Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulationdel Barrio, Laura; Martín-de-Saavedra, María Dolores; Romero Jódar, Alejandro CSIC ORCID; Parada, Esther; Egea, Javier; Ávila, Jesús CSIC ORCID ; McIntosh, John Michael; Wonnacott, Susan; López, Manuela G.artículo
closedAccessaccesoRestringido.pdf.jpg2014New melatonin- N, N -dibenzyl(N -methyl)amine hybrids: Potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for alzheimers diseaseLópez-Iglesias, Beatriz CSIC; Pérez, Concepción CSIC ORCID; Morales-García, José A. CSIC ORCID; Alonso-Gil, Sandra CSIC; Pérez Castillo, Ana CSIC ORCID; López, Manuela G.; Conde, Santiago CSIC; Rodríguez-Franco, María Isabel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2013Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemiaLorrio, Silvia; Gómez-Rangel, Vanessa; Negredo, Pilar; Egea, Javier; León, Rafael CSIC ORCID ; Romero Jódar, Alejandro CSIC ORCID; Dal-Cim, Tharine.; Villarroya, Mercedes; Rodríguez-Franco, María Isabel CSIC ORCID ; Conde, Santiago CSIC; Arce, Mariana P. CSIC; Roda, José María; García, Antonio G.; López, Manuela G.artículo
closedAccess2010Novel Tacrine – 8-Hydroxyquinoline Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Neuroprotective, Cholinergic, Antioxidant, and Copper-Complexing PropertiesFernández Bachiller, María Isabel; Pérez, Concepción CSIC ORCID; González Muñoz, Gema C.; Conde, Santiago CSIC; López, Manuela G.; Villarroya, Mercedes; García, Antonio G.; Rodríguez-Franco, María Isabel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2013Nrf2 participates in depressive disorders through an anti-inflammatory mechanismLorrio, Silvia; Lastres-Becker, Isabel CSIC ORCID; Cuadrado, Antonio CSIC ORCID; López, Manuela G.artículo
closedAccess2010Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow’s neuroprotective therapies against neurodegenerative diseasesGonzález Muñoz, Gema C.; Arce, Mariana P. CSIC; López, Beatriz; Pérez, Concepción CSIC ORCID; Villarroya, Mercedes; López, Manuela G.; García, Antonio G.; Conde, Santiago CSIC; Rodríguez-Franco, María Isabel CSIC ORCID artículo
closedAccessaccesoRestringido.pdf.jpg2013PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in miceLorrio, Silvia; Romero Jódar, Alejandro CSIC ORCID; González-Lafuente, Laura; Lajarín-Cuesta, Rocío; Martínez-Sanz, Francisco J.; Estrada, Martín CSIC ORCID CVN; Samadi, Abdelouahid CSIC ORCID; Marco-Contelles, José CSIC ORCID; Rodríguez-Franco, María Isabel CSIC ORCID ; Villarroya, Mercedes; López, Manuela G.; Ríos, Cristobal de losartículo
closedAccessaccesoRestringido.pdf.jpg2016Reactive oxygen species production in acute hypoxia: oxygen sensing by mitochondrial complex I and the role of the sodium/calcium exchanger NCLXHernansanz-Agustín, Pablo; Ramos, Edurne; Navarro, Elisa; Parada, Esther; Moreno Capellán, Laura CSIC; Izquierdo-Álvarez, Alicia; Buendía Abaitua, Izaskun; Cogolludo, Angel; Egea Maiquez, Javier; López, Manuela G.; Martínez-Ruiz, Antonio CSIC ORCIDpóster de congreso
openAccessacs.jmedchem.1c01883.pdf.jpgmar-2022Resveratrol-Based MTDLs to Stimulate Defensive and Regenerative Pathways and Block Early Events in Neurodegenerative CascadesHerrera-Arozamena, Clara CSIC ORCID CVN; Estrada-Valencia, M.; López-Caballero, Patricia CSIC ORCID; Pérez, Concepción CSIC ORCID; Morales-García, José A. CSIC ORCID; Pérez-Castillo, Ana; Sastre, Eric del; Fernández-Mendívil, Cristina; Duarte, Pablo; Michalska, Patrycja; Lombardía, José; Senar, Sergio; León, Rafael CSIC ORCID ; López, Manuela G.; Rodríguez-Franco, María Isabel CSIC ORCID artículo
closedAccess2009Tacrine – Melatonin Hybrids as Multifunctional Agents for Alzheimer’s Disease, with Cholinergic, Antioxidant, and Neuroprotective PropertiesFernández Bachiller, María Isabel; Pérez, Concepción CSIC ORCID; Campillo, Nuria E. CSIC ORCID ; Páez, Antonio; González Muñoz, Gema Cristina; Usán, Paola; García Palomero, Esther; López, Manuela G.; Villarroya, Mercedes; García, Antonio G.; Martínez, Ana; Rodríguez-Franco, María Isabel CSIC ORCID artículo
closedAccess2009Tacripyrines, the first tacrine-dihydropyridine hybrids, as multitarget-directed ligands for the treatment of Alzheimer’s diseaseMarco-Contelles, José CSIC ORCID; León, Rafael CSIC ORCID ; de los Ríos, Cristóbal; Samadi, Abdelouahid CSIC ORCID; Bartolini, Manuela; Andrisano, Vincenza; Huertas, Óscar; Barril, Xavier; Luque Garriga, Francisco Javier; Rodríguez-Franco, María Isabel CSIC ORCID ; López, Beatriz; López, Manuela G.; García, Antonio G.; do Carmo Carreiras, María; Villarroya, Mercedesartículo