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openAccessMultiple substrate recognition.pdf.jpg23-abr-2021Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clampingMárquez-Moñino, M.Á.; Ortega-García, Raquel CSIC; Shipton, Megan L.; Franco-Echevarría, E. CSIC ORCID; Riley, Andrew M.; Sanz-Aparicio, J. CSIC ORCID; Potter, Barry V.L.; González, Beatriz CSIC ORCIDartículo
openAccessNADP+ Binding.pdf.jpg29-nov-2012NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimerGonzález, Beatriz CSIC ORCID; Garrido, Francisco CSIC; Ortega, Rebeca CSIC; Revilla-Guarinos, Ainhoa; Sanz-Aparicio, J. CSIC ORCID; Pajares, María A. CSIC ORCID artículo
openAccessinvertases.pdf.jpgago-2011Non-catalytic domain of invertases: the key for oligomerization and specificitySainz-Polo, M. Ángela CSIC; González, Beatriz CSIC ORCID; Fernández-Lobato, María; Lafraya, Álvaro; Marín Navarro, Julia CSIC ORCID; Polaina Molina, Julio CSIC ORCID; Sanz-Aparicio, J. CSIC ORCID; Alvaro, Miguelcomunicación de congreso
closedAccessaccesoRestringido.pdf.jpg2018Noncatalytic aspartate at the exonuclease domain of proofreading DNA polymerases regulates both degradative and synthetic activitiesPrado, Alicia del; Franco-Echevarría, E. CSIC ORCID; González, Beatriz CSIC ORCID; Blanco, Luis CSIC ORCID ; Salas, Margarita CSIC ORCID ; Vega, Miguel de CSIC ORCID artículo
openAccessPilot Production of SARS-CoV-2 Related Proteins.pdf.jpg23-dic-2020Pilot Production of SARS-CoV-2 Related Proteins in Plants: A Proof of Concept for Rapid Repurposing of Indoor Farms Into Biomanufacturing FacilitiesDiego-Martin, Borja CSIC ORCID; González, Beatriz CSIC ORCID; Vázquez Vilar, Marta; Selma, Sara; Mateos-Fernández, Rubén; Gianoglio, Silvia; Fernández-del-Carmen, Asun CSIC ORCID; Orzáez, Diego CSIC ORCIDartículo
openAccessPilot production of SARSCoV2 related proteins in plants.pdf.jpg13-oct-2020Pilot production of SARS-CoV-2 related proteins in plants: a proof of concept for rapid repurposing of indoors farms into biomanufacturing facilitiesDiego-Martin, Borja CSIC ORCID; González, Beatriz CSIC ORCID; Vázquez Vilar, Marta; Selma, Sara; Mateos-Fernández, Rubén; Gianoglio, Silvia; Fernández-del-Carmen, Asun CSIC ORCID; Orzáez, Diego CSIC ORCIDpreprint
openAccessInositol_polyphosphate.pdf.jpg22-ago-2011Site directed mutagenesis to the rescue: unravelling conformational changes of Inositol 1,3,4,5,6 pentakisphosphate 2-kinase.Baños-Sanz, J.I. CSIC; Sanz-Aparicio, J. ; Brearley, Charles A.; González, Beatriz CSIC ORCIDcomunicación de congreso
openAccessJ Physiol 2008.pdf.jpg27-mar-2008Slow- and fast-twitch rat hind limb skeletal muscle phenotypes 8 months after spinal cord transection and olfactory ensheathing glia transplantationNegredo, Pilar; Rivero, José-Luis L.; González, Beatriz CSIC ORCID; Ramón-Cueto, Almudena CSIC; Manso-Martínez, Rafaelartículo
closedAccessaccesoRestringido.pdf.jpg2014Structural analysis of glucuronoxylan-specific Xyn30D and its attached CBM35 domain gives insights into the role of modularity in specificitySainz-Polo, M. Ángela CSIC; Valenzuela, S.V.; González, Beatriz CSIC ORCID; Pastor, F. I. Javier; Sanz-Aparicio, J. CSIC ORCIDartículo
openAccessFernández-LobatoM_StructuralAnalysisofB-Fructofuranosidase.pdf.jpg25-mar-2016Structural analysis of β-fructofuranosidase from xanthophyllomyces dendrorhous reveals unique features and the crucial role of N-Glycosylation in oligomerization and activityRamírez-Escudero, Mercedes CSIC ORCID; Gimeno-Pérez, María CSIC ORCID; González, Beatriz CSIC ORCID; Linde, Dolores CSIC ORCID ; Merdzo, Z.; Fernández Lobato, María CSIC ORCID; Sanz-Aparicio, J. CSIC ORCIDartículo
openAccessJBC-2016-Ramírez.pdf.jpg27-sep-2016Structural and Functional Characterization of a Ruminal β-Glycosidase Defines a Novel Subfamily of Glycoside Hydrolase Family 3 with Permuted Domain TopologyRamírez-Escudero, Mercedes CSIC ORCID; Pozo, Mercedes V. del; Marín Navarro, Julia CSIC ORCID; González, Beatriz CSIC ORCID; Golyshin, Peter N.; Polaina Molina, Julio CSIC ORCID; Ferrer, Manuel CSIC ORCID; Sanz-Aparicio, J. CSIC ORCIDartículo
openAccess30-abr-2010Structural and kinetic analysis of Schwanniomyces occidentalis invertase reveals a new oligomerization pattern and the role of its supplementary domain in substrate bindingÁlvaro-Benito, Miguel CSIC ORCID; Polo, Aitana CSIC; González, Beatriz CSIC ORCID; Fernández-Lobato, María; Sanz-Aparicio, J. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2012Structural and kinetic insights reveal that the amino acid pair Gln-228/Asn-254 modulates the transfructosylating specificity of Schwanniomyces occidentalis β-fructofuranosidase, an enzyme that produces prebioticsÁlvaro-Benito, Miguel CSIC ORCID; Sainz-Polo, M. Ángela CSIC; González-Pérez, David CSIC ORCID; González, Beatriz CSIC ORCID; Plou Gasca, Francisco José CSIC ORCID ; Fernández Lobato, María CSIC ORCID; Sanz-Aparicio, J. CSIC ORCIDartículo
openAccess22-ene-2010Structural insights into the specificity of Xyn10B from paenibacillus barcinonensis and its improved stability by forced protein evolutionGallardo, Oscar CSIC; Pastor, F. I. Javier; Polaina Molina, Julio CSIC ORCID; Díaz, P.; Lysek, Robert; Vogel, Pierre; Isorna, Pablo CSIC; González, Beatriz CSIC ORCID; Sanz-Aparicio, J. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg12-oct-2008Targeted polypharmacology: Discovery of dual inhibitors of tyrosine and phosphoinositide kinasesApsel, Beth; Blair, Jimmy A.; González, Beatriz CSIC ORCID; Nazif, Tamim M.; Feldman, Morri E.; Aizenstein, Brian; Hoffman, Randy; Williams, Roger L.; Shokat, Kevan M.; Knight, Zachary A.artículo
openAccessJ. Biol. Chem.-2017-Franco-Echevarría-10534-48.pdf.jpg2017The crystal structure of mammalian inositol 1,3,4,5,6-pentakisphosphate 2-kinase reveals a new zinc-binding site and key features for protein function.Franco-Echevarría, E. CSIC ORCID; Sanz-Aparicio, J. CSIC ORCID; Brearley, Charles A.; González-Rubio, Juana M. CSIC; González, Beatriz CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2000The crystal structure of tetrameric methionine adenosyltransferase from rat liver reveals the methionine-binding siteGonzález, Beatriz CSIC ORCID; Pajares, María A. CSIC ORCID ; Hermoso, Juan A. CSIC ORCID; Álvarez, Luis; Garrido, Francisco CSIC; Sanz-Aparicio, J. CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2015The new InsP<inf>3</inf>Kinase inhibitor BIP-4 is competitive to InsP<inf>3</inf> and blocks proliferation and adhesion of lung cancer cellsSchröder, D.; Tödter, K.; González, Beatriz CSIC ORCID; Franco-Echevarría, E. CSIC ORCID; Rohaly, G.; Blecher, C.; Lin, H.-Y.; Mayr, G.W.; Windhorst, S.artículo
openAccessRole_Garcia_Art2020.pdf.jpg2020The Role of ABA in Plant Immunity is Mediated through the PYR1 ReceptorGarcía-Andrade, Javier CSIC ORCID; González, Beatriz CSIC ORCID; González-Guzmán, Miguel CSIC ORCID; Rodríguez, Pedro L. CSIC ORCID; Vera, Pablo CSIC ORCIDartículo
openAccessgkx685.pdf.jpg2017The structure of transcription termination factor Nrd1 reveals an original mode for GUAA recognitionFranco-Echevarría, E. CSIC ORCID; González-Polo, Noelia CSIC ORCID; Zorrilla, Silvia CSIC ORCID ; Martínez-Lumbreras, Santiago CSIC ORCID; Santiveri, Clara M. CSIC ORCID; Campos-Olivas, Ramón CSIC ORCID; Sánchez, Mar CSIC; Calvo, Olga CSIC ORCID; González, Beatriz CSIC ORCID; Pérez Cañadillas, José Manuel CSIC ORCID artículo