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openAccessCrystal structure.pdf.jpg13-jun-2022Crystal structure of a family VIII β-lactamase fold hydrolase reveals the molecular mechanism for its broad substrate scopeCea-Rama, Isabel CSIC ORCID; Coscolín, Cristina CSIC ORCID; González-Alfonso, José L.; Raj, Jog; Vasiljević, Marko; Plou Gasca, Francisco José CSIC ORCID ; Ferrer, Manuel CSIC ORCID; Sanz-Aparicio, J. CSIC ORCIDartículo
openAccessCrystal structure.pdf.jpg20-jul-2019Crystal structure of promiscuous serine ester hydrolasesCea-Rama, Isabel CSIC ORCID; Coscolín, Cristina CSIC ORCID; Ferrer, Manuel CSIC ORCID; Sanz-Aparicio, J. CSIC ORCIDpóster de congreso
openAccess2021_Hoppner_Crystal_FEBS_Journal.pdf.jpg2021Crystal structures of a novel family IV esterase in free and substrate-bound formHöppner, Astrid; Bollinger, Alexander; Kobus, Stefanie; Thies, Stephan; Coscolín, Cristina CSIC ORCID; Ferrer, Manuel CSIC ORCID; Jaeger, Karl-Erich; Smits, Sander H. J.artículo
openAccessdetermipatter.pdf.jpg28-nov-2017Determinants and prediction of esterase substrate promiscuity patternsMartínez-Martínez, Mónica CSIC ORCID; Coscolín, Cristina CSIC ORCID; Santiago, Gerard; Chow, Jennifer; Stogios, Peter J.; Bargiela, Rafael CSIC ORCID; Gertler, Christoph; Navarro-Fernández, José; Bollinger, Alexander; Thies, Stephan; Méndez-García, Celia; Popovic, Ana; Brown, Greg; Chernikova, Tatyana; García-Moyano, Antonio; Bjerga, Gro Elin Kjæreng; Pérez-García, Pablo CSIC ORCID; Hai, Tran; Pozo, Mercedes V. del; Stokke, Runar; Steen, Ida H.; Cui, Hong; Xu, Xiaohui; Nocek, Boguslaw P.; Alcaide, María CSIC; Distaso, Marco; Mesa, Victoria; Peláez, Ana I.; Sánchez, Jesús; Buchholz, Patrick C. F.; Pleiss, Jürgen; Fernández-Guerra, Antonio; Glöckner, Frank Oliver; Golyshina, Olga V.; Yakimov, Michail M.; Savchenko, Alexei; Jaeger, Karl-Erich; Yakunin, Alexander F.; Streit, Wolfgang R.; Golyshin, Peter N.; Guallar, Victor; Ferrer, Manuel CSIC ORCID; INMARE Consortiumartículo
openAccessNature Communications_Marasco_2023.pdf.jpg24-feb-2023Enzyme adaptation to habitat thermal legacy shapes the thermal plasticity of marine microbiomesMarasco, Ramona; Fusi, Marco; Coscolín, Cristina CSIC ORCID; Barozzi, Alan; Almendral, David CSIC ORCID; Bargiela, Rafael CSIC ORCID; Gohlke neé Nutschel, Christina; Pfleger, Christopher; Dittrich, Jonas; Gohlke, H.; Matesanz, Ruth CSIC ; Sánchez-Carrillo, Sergio; Mapelli, Francesca; Chernikova, Tatyana; Golyshin, Peter N.; Ferrer, Manuel CSIC ORCID; Daffonchio, Danieleartículo
openAccessGenetically engineered.pdf.jpg16-dic-2019Genetically engineered proteins with two active sites for enhanced biocatalysis and synergistic chemo- and biocatalysisAlonso, Sandra; Santiago, Gerard; Cea-Rama, Isabel CSIC ORCID; Fernández-López, Laura; Coscolín, Cristina CSIC ORCID; Modregger, Jan; Ressmann, Anna K.; Martínez-Martínez, Mónica CSIC ORCID; Marrero, Helena; Bargiela, Rafael CSIC ORCID; Pita, Marcos CSIC ORCID ; González-Alfonso, José L.; Briand, Manon L.; Rojo, David; Barbas, Coral; Plou Gasca, Francisco José CSIC ORCID ; Golyshin, Peter N.; Shahgaldian, Patrick; Sanz-Aparicio, J. CSIC ORCID; Guallar, Victor; Ferrer, Manuel CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg2021Promiscuous Esterases Counterintuitively Are Less Flexible than Specific OnesNutschel, Christina; Coscolín, Cristina CSIC ORCID; David, Benoit; Mulnaes, David; Ferrer, Manuel CSIC ORCID; Jaeger, Karl-Erich; Gohlke, Holgerartículo
openAccessStructure and evolutionary trace-assisted.pdf.jpg18-abr-2021Structure and evolutionary trace-assisted screening of a residue swapping the substrate ambiguity and chiral specificity in an esteraseCea-Rama, Isabel CSIC ORCID; Coscolín, Cristina CSIC ORCID; Katsonis, Panagiotis; Bargiela, Rafael CSIC ORCID; Golyshin, Peter N.; Lichtarge, Olivier; Ferrer, Manuel CSIC ORCID; anz-Aparicio, J.artículo
openAccessCap_Domain.pdf.jpg31-ene-2023The Mobility of the Cap Domain Is Essential for the Substrate Promiscuity of a Family IV Esterase from Sorghum Rhizosphere MicrobiomeDistaso, Marco; Cea-Rama, Isabel CSIC ORCID; Coscolín, Cristina CSIC ORCID; Chernikova, Tatyana N; Tran, Hai; Ferrer, Manuel CSIC ORCID; Sanz-Aparicio, J. CSIC ORCID; Golyshin, Peter Nartículo
openAccessChemComm_FernándezLópez_et_al_2023.pdf.jpg1-ago-2023Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitorFernandez-Lopez, Laura; Cea-Rama, Isabel CSIC ORCID; Alvarez-Malmagro, Julia; Ressmann, Anna K.; Gonzalez-Alfonso, Jose L.; Coscolín, Cristina CSIC ORCID; Shahgaldian, Patrick; Plou Gasca, Francisco José CSIC ORCID ; Modregger, Jan; Pita, Marcos CSIC ORCID ; Sanz-Aparicio, J. CSIC ORCID; Ferrer, Manuel CSIC ORCIDartículo
closedAccessaccesoRestringido.pdf.jpg11-dic-2020Tuning the Properties of Natural Promiscuous Enzymes by Engineering Their Nano-environmentGiunta, C.I.; Cea-Rama, Isabel CSIC ORCID; Alonso, Sandra; Briand, Manon L.; Bargiela, Rafael CSIC ORCID; Coscolín, Cristina CSIC ORCID; Corvini, P.F.X.; Ferrer, Manuel CSIC ORCID; Sanz-Aparicio, J. CSIC ORCID; Shahgaldian, Patrickartículo